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The following pathogenic pathways, including thrombotic microangiopathy [25], inflammation, tubular cell toxicity [26], altered intra-glomerular hemodynamic [27], crystal nephropathy [28], and rhabdomyolysis [29], can be used to indicate drug-induced nephrotoxicity

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Moon DO, Kim MO, Choi YH, Hyun JW, Chang WY, Kim GY (2010) Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation