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MicroRNAs in hyperglycemia induced endothelial cell dysfunction

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In addition to the effects on fibroblasts, PRP reduces lipid peroxidation and alleviates ferroptosis in endothelial cells treated with high glucose and ferroptosis inducer Erastin, improving cell regeneration and proliferation to promote diabetic ulcer healing [80]

RNA-sequencing data processing Paired-end RNA-seq data obtained from three biological replicates were analyzed under the conditions of vehicle (Veh), 10 M NAM, 100 M H 2 O 2 , and 100 M H 2 O 2 in combination with 10 M NAM for 4 or 10 days with osteogenic medium in MC3T3-E1 preosteoblasts