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Considering that increased oxidative stress and redox imbalance in AECIIs are known components of IPF pathogenesis, we sought to investigate if CYB5R3 redox activity was altered in AECIIs from IPF lungs

The pattern of observed effects has been characterized as supporting ECM turnover and remodeling, increasing the expression of structural matrix components while modulating the balance between matrix-building and matrix-degrading enzymes