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Unlike ingredients that work only on the skins surface, it gets to work deep within, repairing, protecting, and rejuvenating skin at the cellular level

Proprioception abnormalities secondary to CNS lesions, such as parietal cortex stroke [ 124 ], neuromyelitis optica [ 125 ], or cervical myelopathy [ 126 ] may also cause pseudoathetosis

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10.1038/cr.2008.327 279 WujekJ

As an example, if a drug such as lithium is associated with adverse effects when administered in a single dose, divided doses may be better tolerated