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also found a significant relationship between MS and B 12 deficiency.[13] Another study reported that serum B 12 concentration in MS patients is related to the age of onset of the disease.[16] According to that report, B 12 concentration was significantly lower in those who experienced the onset of first neurological symptoms prior to age 18 years compared to patients in whom the disease first manifested after age 18

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Would this be some kind of rebound effect, like an immune (or autoimmune) reaction to the injection/B12

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PMID: 36516757 Brain Behav Immun The role of CD38 in inflammation-induced depression-like behavior and the antidepressant effect of (R)-ketamine