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What counts is both ineffective erythropoiesis and ferroptosis in -thalassemia are intricately linked to the iron metabolism and Reactive oxygen species homeostasis

After this signaling pathway is activated by inflammatory factors, it promotes the expression of inflammatory factors at the transcriptional level as well, thus forming a loop and producing an amplification effect to aggravate inflammation response [47-51]

In particular, damaged tubular cells are an important source of M2 macrophage polarization factors, such as macrophage colony-stimulating factor, granulocyte-macrophage colony stimulating factor, and Nectrin 1 (89)

DLCO, diffusing capacity for carbon monoxide

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