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Quantitative analysis confirmed that the inhibitory effect of aloe emodin is better than that of emodin, suggesting distinct mechanisms for each compound against breast cancer metastasis [503]

For instance, IGF-I attenuated the response of theMCF-7 BC cell line to doxorubicin and paclitaxel by at least two mechanisms: induction of proliferation and inhibition of apoptosis (Zeng et al., 2009)

Activation of the farnesoid X receptor (FXR), a ligandactivated nuclear hormone receptor that is a key regulator of bile acid homeostasis, has demonstrated clinical benefit in patients with PSC, as shown by the sustained reduction in serum alkaline phosphatase levels induced by multiple FXR agonists, including obeticholic acid in a phase 2 trial (NCT02177136)

Asparagine bioavailability governs metastasis in a model of breast cancer

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These findings are in line with previous studies, further confirming the association between CKD and retinal lesions, while uncovering the potential mechanisms of ferroptosis in retinal degeneration, offering new insights to the existing literature and expanding the pathological research on retinal lesions