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Key features of metabolic reprogramming in thyroid cancer Glucose metabolism reprogramming Reprogramming of glucose metabolism is a key factor driving the malignant progression of thyroid cancer, providing energy and biosynthetic precursors for rapid tumor growth

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The classical pro-inflammatory M1 state is driven by aerobic glycolysis, whereas the anti-inflammatory M2 state primarily relies on oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO)

PACs have been found to inhibit ferroptosis and play a role in a variety of diseases by altering the expression of iron-related factors

These are prescription medications requiring physician oversight, BMI eligibility criteria (typically 30 or 27 with comorbidities), and management of gastrointestinal side effects during dose escalation