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Conversely, it should be noted that some studies suggest that very high levels of NO, such as those produced by NO donors or potentially iNOS, may actually negatively regulate Th1 differentiation required for anti-tumor immunity by leading to the S-nitrosylation of key post-transcriptional regulators of Th1 cytokines and transcription factors (8890)

CM: Conceptualization, Data curation, Methodology, Resources, Supervision, Validation, Visualization, Writing original draft, Writing review and editing

Consistent increases in cellular migration have been recorded, highlighting its role in coordinated cell movement during tissue restructuring

Cancer 139, 26352645

It is driven by factors such as vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF), EDN-1, fibroblast growth factor 2 (FGF-2) produced by mast cells, keratinocytes, and fibroblasts, stimulating endothelial cells [153, 154]

Obesity occurs in more than 40% of US women [2] and is an established risk and progression factor for several breast cancer subtypes including triple-negative breast cancer (TNBC) [3]