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FIGURE 5 3.6 CPT1A protects against SAP in mice by inhibiting the NLRP3/GSDMD-mediated pyroptosis signalling pathway To investigate the protective mechanism of CPT1A in SAP, we assessed the expression changes of proteins involved in NLRP3 inflammasome activation

Systemic inflammatory responses, as well as superoxide, nitric oxide, and peroxynitrite could impair cardiac CPT1 activity in vivo and in vitro , thus leading to myocardial dysfunction (Fukumoto et al., 2002)