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Both male and female transgenic 5xFAD mice displayed the development of amyloid plaques in the midbrain and thalamus region, frontal cortex, and the hippocampus

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Paracrine signaling provides alternative mechanisms: Conditioned media from umbilical cord mesenchymal stem cells (UCMSC-CM) restores stemness in degenerated NP cells and enhances NPPC differentiation [94], while exosomes from normal nucleus pulposus progenitor cells (N-NPSC-exo) transfer microRNAs that support AF cell growth and disc repair (Fig

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