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The recruitment of TAMs is an active process largely driven by ROS

For instance, kaempferol (a flavonol abundant in foods like saffron, apples, and leafy greens) protects against -synuclein toxicity: in PD models it increases neuronal viability, decreases misfolded -synuclein aggregates, prevents TH-positive neuron loss, and attenuates astrocyte activation (as indicated by reduced glial fibrillary acidic protein, GFAP) (19)

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doi: 10.1111/j.1471-4159.2008.05430.x

In contrast, the second individual may experience elevated uric acid levels due to increased purine intake and oxidative stress

doi: 10.1038/s41598-021-97127-4 87 ErgulAKelly-CobbsAAbdallaMFaganSC