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Moreover, the selection of an appropriate detection method is crucial and must match the analytes characteristics

Similarly to our observations, the positive effect of SHBG toward PCG1 has already been reported in a previous study of Saez-Lopez and collaborators [59], who demonstrated that human SHBG transgenic mice, expressing high SHBG levels were characterized by increased expression levels of PCG1 at both mRNA and protein levels, underlying the ability of SHBG to restore PPAR effects by activating the transcription of its genes targets including mitochondrial PCG1

doi: 10.1016/j.amepre.2022.01.012

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IT-T and EG-B: visualization