glutathione cat Enzymatic antioxidant defense systems. CAT: catalase; SOD: superoxide Estimation of catalase (CAT), glutathione

[DOI] [PubMed] [Google Scholar] 476

They are activated in the response to ROS and involved in the apoptotic response to oxidative stress

From flavors to strengths, robust palates from all over the world have flocked to experience the legend of the Eonsmoke Disposables

136 RustM

Blocked blood supply to a part of the intestines

Resistance to conventional chemotherapy or radiotherapy frequently involves upregulation of antioxidant pathways (e.g., the NRF2 and System Xc -GSH-GPX4 axis), rendering such cells highly vulnerable to ferroptosis ( ICIs ) can synergistically activate anti-tumor immune responses by promoting the release of tumor antigens and damage-associated molecular patterns ( This review aims to systematically analyze the molecular mechanisms of ferroptosis (lipid peroxidation drive, collapse of antioxidant defenses, and regulation of iron/lipid metabolism), its crosstalk with other cell death pathways, and key regulatory networks (e.g., NRF2, p53, Hippo-YAP pathways)