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Potential Research Applications: Melanogenesis and skin pigmentation studies UV protection and tanning research models Libido and sexual function investigations Energy regulation and melanocortin receptor research For laboratory research only

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In one aspect, the disclosure provides a vector comprising a regulatory element operably linked to an enzyme-coding sequence encoding a CRISPR enzyme comprising one or more nuclear localization sequences

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These early safety and pharmacokinetic studies preceded Phase 2 dose-ranging work in 20042006 and the Phase 3 pivotal trials that began in 2006

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