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Many patients continue to experience persistent or relapsing disease activity, and current treatment options are limited by teratogenicity, systemic toxicity, and tolerability concerns

Reynolds and colleagues observed that patients with low serum folate levels undergoing treatment with various antidepressant drugs had poorer therapeutic outcomes (65)

NICE guideline [NG239] Vitamin B12 deficiency in over 16s: diagnosis and management As a stakeholder I was able to add my comments and yours to the consultation on the draft guidelines last summer

It also plays a role in brain function, supporting neurons and cell formation

"Nicotinamide N-methyltransferase promotes excessive accumulation of fat and is a viable target for treating obesity." Nature Communications

biochemical testing is needed to distinguish between these conditions