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it makes possible mortality deconvolution, an approach to improve understanding of the relationship between biological and demographic parameters, and in the case of rapamycin, it points to the presence of ranked sequences of life-limiting pathologies (the onion model) [61]

PMID 19052378

This metabolic pathway yields the one-carbon unit necessary for the formation of the methyl donor SAM through processes mediated by serine hydroxymethyltransferase 2 (SHMT2) [75]

This multi-component and multi-target systematic intervention model precisely matches the multi-dimensional pathological characteristics of the immune-metabolic network

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