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Additionally, HDAC1 SUMOylation is also found to protect against A toxicity and alleviate AD [84]

Autophagy is a five-stage molecular process involving initiation, nucleation, membrane extension, fusion and degradation (23)

Abby Jean Houk, freshman, Deans List, College of Education and Human Sciences, nutrition and health sciences

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The released SIM inhibits HMGCR, reducing downstream mevalonate pathway metabolites, such as IPP, resulting in GPX4 dysfunction, impaired lipid repair capacity, and LPO accumulation, ultimately inducing ferroptosis and establishing a comprehensive lipid metabolism regulatory axis

Last reviewed February 2, 2022