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doi: 10.1007/s12035-021-02444-4 44 ChidambaramS

Nord et al

Drug concentrations are affected by the abnormal and immature tumor vasculature system, as well as by the activation of drug efflux transporters under the hypoxic tumor environment 52

The crossing of these cellular barriers is essential for the development of the IMD, and although it has been intensively studied, it remains not fully understood