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Muscle growth requires a hormonal environment that supports protein synthesis, recovery, and nutrient partitioning

PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons

Chem Rev 105:27232744 Richard J-M, Louis J, Cantin D (1988) Nephrotoxicity of orellanine, a toxin from the mushroom Cortinarius orellanus

& Schectman, J

Odin et al., 2008)

Additionally, standard in vitro culture conditions fail to replicate hypoxia and nutrient deprivation, which are essential for shaping metabolic plasticity