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In respect to vesicular release, it appears unlikely that filling of vesicles with ATP by VNUT is regulated by [ATP] c (at least for the physiological concentration range), given that VNUT is an active transporter and [ATP] c is rather high

There is abundant evidence of adverse health effects in all of these populations

Consistently, SureQuantbased targeted mass spectrometry using two unique CEST2.2 peptides (LSTGTIEGR and HGEDFAYAFGTNR) revealed that our transgene could also restore CEST2.2 protein levels when introduced in gas1(fc21) mutants (Fig 1L and Appendix Table S2)

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Firstly, combination therapy: The synergistic effects of combining these ESCM with conventional treatments (e.g., chemotherapy, radiotherapy, immunotherapy) should be investigated to enhance therapeutic efficacy and mitigate side effects