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Lou E, Beg MS, Bergsland E, Eng C, Khorana AA, Kopetz S , Lubner S, Saltz L, Shankaran V, Zafar SY

Front Microbiol 12:656380

It manifests as an excessive production of skin cells, resulting in the formation of thickened, red plaques accompanied by inflammation

FSEN1 was identified as a small-molecule inhibitor of FSP1 through chemical screening 118 , and subsequent structural analyses revealed that FSEN1 occupies the substrate-binding pocket of FSP1 in a position analogous to CoQ observed in the enzyme active site, providing structural insight into inhibitor recognition 119