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5.3 Current lack of disease-modifying therapies (DMTs) The most pressing challenge in the current treatment landscape of DPN is the systemic absence of disease-modifying therapies (DMTs)

CuZnHis assemblies significantly downregulate the expression of pro-inflammatory factors related genes (IL-1 and TNF-), and upregulate the expression of anti-inflammatory factors related genes (IL-10 and TGF-) (Fig

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For example, gestational protein restriction in mice decreased H3K4me3 and H4K20me3 while it increased H3K9me3 and H3K27me3 levels on the Igf2 (Insulin-like growth factor-II) locus, resulting in its repression in fetal liver (Strakovsky et al., 2011)

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