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In addition to microvascular changes, retinal neurodegeneration or loss of the retinal pigment epithelium (RPE) also contribute to diabetic retinal damage early in DR, and HG has detrimental effects on RPE cells by producing ROS and decreasing the Gpxs expression (109)

Transcriptomics and metabolomics integration reveals Redox-Dependent metabolic rewiring in breast cancer cells [in eng]

Interestingly, women with UFs have greater endometrial expression of ETAR and a lower expression of ETBR compared to normal endometrium

Furthermore, the long-term outcomes of current interventions are inconsistent and there is limited capacity to reverse established complications (17,4345)

Genetic or pharmacological inhibition of ALDH18A1through knockout, short hairpin RNA delivered using adeno-associated virus (AAV), or the small molecule inhibitor YG1702triggers ferroptosis and impairs both spontaneous and chemically induced hepatocarcinogenesis