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In their experiments, all coumarin derivatives showed antioxidant activity in the DPPH assay, while daphnetin and fraxetin also showed antioxidant activity by inhibiting lipid peroxidation

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A recent study integrating bioinformatics analysis (GSE26440 + FerrDb), LPS-induced MLE-12 cell assays, and CLP mouse models revealed that MAPK14 promotes ferroptosis via TTP53/SLC7A11/GPX4 axis, accompanied by enhanced ROS, MDA, and Fe 2+ accumulation, as well as immunosuppressive neutrophil infiltration (Zhang et al

In a study on presumable celiac disease diagnosed by Crosby-Kugler capsule and clinical symptoms, 4 weeks of exclusive elemental diet (n = 4, Vivonex) achieved similar clinical improvement as gluten-free diet (n = 4)

4.4 Amyotrophic lateral sclerosis ALS, also known as Charcots disease, is a lethal and uncommon neurodegenerative disorder of the central nervous system (143)