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Yet another drawback is that such treatments are usually limited by toxicity

Toxicol In Vitro 17:675680 Gomez-Lechon MJ, Ponsoda X, OConnor E, Donato T, Castell JV, Jover R (2003b) Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS

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Abbreviations AD: Alzheimer's disease 3xTg AD: Triple transgenic mouse model of Alzheimer's disease AChE: Acetylcholinesterase AlCl3: Aluminium chloride ALS: Amyotrophic lateral sclerosis APP: Amyloid precursor protein APPsw: APP with Swedish mutation A1R, A2AR, A2BR, A3R: Adenosine receptor subtypes A1, A2A, A2B, A3 A: Amyloid-beta AOs: Amyloid-beta oligomers ADAM10: A disintegrin and metalloproteinase domain-containing protein 10 (-secretase) AMP: Adenosine monophosphate ATP: Adenosine triphosphate BACE1/2: -Site APP cleaving enzyme 1/2 (-secretases) BAX: B-cell lymphoma 2-associated X protein (pro-apoptotic) BBB: Blood-brain-barrier BChE: Butyrylcholinesterase Bcl2: B-cell lymphoma 2 (anti-apoptotic protein) BDNF: Brain-derived neurotrophic factor BrdU: Bromodeoxyuridine C

Food Res Int 38(8-9):10511058 Ninfali P, Antonini E, Frati A, Scarpa ES (2017) C-glycosyl flavonoids from Beta vulgaris cicla and betalains from Beta vulgaris rubra: antioxidant, anticancer and antiinflammatory activitiesA review

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