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First of all, intracellular iron generally exists in the form of Fe 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death

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From a research standpoint, extensive, strain-specific multicenter trials that include comprehensive product characterization, standardized outcome measures, and sufficient follow-up are essential to establish minimal effective doses, assess the durability of effects, and identify infrequent adverse events

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The investigators proposed that a team make the decision regarding surgical treatment for PD, taking into account the patients clinical characteristics, treatment efficacy, ease of use, associated risks, and overall quality of life