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Excessive ROS may result in oxidative damage to mitochondrial proteins and DNA, which impairs mitochondrial function, eventually leading to ferroptosis ( The system Xc - -glutathione (GSH)-GPX 4 axis plays a central role in limiting lipid peroxidation

Cancer Res (2010) 70(2):5129

however, there was a trend towards increased Tau phosphorylation on Ser396 in untreated TBI mice compared to Sham and this trend persisted for TBI mice which had been pretreated with Immunocal (Figure 2B)