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Future studies should adopt quantitative and standardized methods, such as transmission electron microscopy with immunogold labeling, 221 subcellular fractionation combined with mass spectrometry, 222 and super-resolution imaging in tissue sections, 223 to allow more reliable and comparable evaluation

Its distinct morphological, biochemical, immunological, and genetic characteristics set it apart from other RCD mechanisms [72]

Inflammatory bowel disease is a result of immunologic imbalances at the interface of the intestinal lumen (the hollow part of the digestive tract through which food passes) and the intestinal epithelium (the inward-facing surface of the intestinal wall)

Glutathione plays a crucial role in maintaining normal protein structures, facilitating waste disposal in the liver and neutralizing harmful free radicals throughout the body

To determine whether GSH depletion can also exert protective effects in a primarily MASH model, we overexpressed Chac1 in mouse liver using AAV8 followed by challenging mice with methionine/choline-deficient diets (MCDs) to induce MASH

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