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In certain cases, M2 macrophages may promote tumor cell growth, metastasis, invasion and drug resistance by secreting immunosuppressive factors and enhancing tumor angiogenesis through cytokines (such as VEGF) (48-52)

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Luteolin has the natural advantages of low toxicity and high efficacy, and has become a candidate drug for a variety of diseases, with different potential mechanisms of action and considerable potential for clinical application [17]