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Again, the loss of FlnA, in combination with formin 2 knock-out, leads to smaller body size, thinned muscle and skeletal wall as well as defects in cardiac valve in a mouse model [116]

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The main causes of migraine include mutations in the MTHFR gene, atypical vitamin D levels, the presence of inflammatory mediators in the environment of nerves and cerebrospinal fluid, reduced serotonin levels, impaired mitochondrial functionality, and reduced metabolic enzyme activity [9, 10]

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307,308,309 Endothelial dysfunction is well recognized in DPN