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In one study, a mouse model with a selective knockout of the Gq/11 subunits in AgRP neurons was generated to gain an insight on the relevance of this specific ghrelin-activated pathway in the context of appetite regulation

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Tirzepatide receptor pharmacology and predicted receptor occupancy GIPR-forward dual-incretin design, cAMP-biased GLP-1R with low beta-arrestin, GCGR negative control (EC50 329 nM)