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The mineral vitamins premix provided the following per kilogram of diet: vitamin A: 6,000 IU, vitamin E: 800 mg, vitamin D3: 4,000 IU, vitamin K3: 30 mg, vitamin B1: 25 mg, vitamin B2: 25 mg, vitamin B6: 80 mg, niacin: 300 mg, vitamin B12: 0.2 mg, pantothenic acid: 200 mg, folic acid: 10 mg, biotin: 4 mg, choline: 5,000 mg

The role of the Wnt pathway in both reactive and nonreactive state of astrocytes has been examined in various studies, with evidence suggesting that it influences astrocytes communication with other cells in the CNS by stimulating the transcription of synaptogenic factors 120

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However, after prolonged exposure to Mn, autophagy function is impaired, and subsequent cytotoxicity occurs (Zhang et al., 2013), suggesting that pathological levels of Mn exposure dysregulated autophagy function