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Pathology Outlines Melanotic macule Pigmented lesions of the oral mucosa and perioral tissues: a flow chart for the diagnosis and some recommendations for the management ScienceDirect Smokers melanosis . Oral pigmentation seen in heavy smokers . Investigations have shown ability of melanin to bind to noxious substances. . Exposure to polycyclic amines ( Nicotine & benzpyrene) has shown Pigmented Lesions Pocket Dentistry Melanotic Macules, Naevi, and Melanoma Springer Nature Link Pigmented conjunctival lesions CMAJ
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