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In a pilot study in Thailand, Sangsuwan and Asawanonda tested the influence of daily intake of oral collagen (5 g) for 4 weeks on skin elasticity, especially in sun-exposed areas, in a randomized, double-blind, placebo-controlled trial (in a total of 36 women, aged 4060 years, where one-half of the participants were in the treatment group [ n = 18] or the placebo group [ n = 18]) [39]

Regulation of copper chaperone protein expression Copper chaperones play a crucial role in maintaining cellular copper homeostasis by facilitating the transfer of copper ions to target proteins and organelles

The practical effect of longer duration is that trials can measure outcomes over weekly and multi week windows with consistent exposure, rather than focusing only on short time course endpoints

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Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation