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Further evidence for the involvement of miRNAs in the mechanism of ECT comes from a study involving 64 patients with TRD: At baseline, expression of miRNA-223-3p was significantly lower in responders compared to non-responders and demonstrated moderate predictive capacity for ECT response (AUC = 0.76, 95% CI = 0.60.91) [28]

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CIPN is a serious dose-limiting toxicity that requires individualized prevention and treatment strategies in patients with cancer in order to minimize negative impact on patient QOL

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Additionally, the rs9939609a variant of FTO has been associated with impaired D2/3R signaling and increased reward sensitivity (117, 119, 120)