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All statistical procedures were performed using GraphPad Prism version 8.0

Sertraline, as an SHMT inhibitor, when combined with mitochondrial inhibitors (such as the antimalarial artemether), induces G1-S phase cell cycle arrest and produces serine-selective antitumor activity in a mouse xenograft model of breast cancer [168]

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Despite decades of persistent efforts by scholars, clinical treatment is still focused on alleviating patients pain and reducing the incidence of disability, including physiotherapy, closed therapy, and surgery, 3,4 which not only fail to cure the disease at the etiological level but also may lead to complications associated with drugs and surgery