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The primary cause of HIF-1 activation is hypoxia due to disruption of the alveolar-capillary barrier, leading to pulmonary edema, immune cell infiltration, and impaired gas exchange (327)

All subjects involved in the study signed an informed consent agreement

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Consistent with the histological changes, the serum blood urea nitrogen (BUN) and creatinine (Cr) levels were markedly higher in the I/R group than in the Sham group (see Fig

Pillar III: Tame the Toxins Most people see improvement after addressing the first two pillars