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The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events

Although the Pin1 isomerization site in the cPKC isoforms is missing in PKC (18), we found that PKC possesses a distinct Pin1 binding site within its regulatory regions, which is absent in cPKC isoforms

1992 Oct 19-26;47 (42-43):964-6

10(10):31063126 Lopaschuk GD, Barr R, Thomas PD, Dyck JRB (2003) Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase

Defective decidualization has been postulated to impair proper modulation of endometrial immune cells in a pregnancy-friendly manner, which could potentially lead to implantation failure or miscarriage (76)