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Therapeutically, targeting adaptive immune pathwayssuch as restoring regulatory T cell (Treg) function, modulating Th17/Th1 responses, or influencing antigen presentationrepresents a potential adjunctive strategy to complement microbiome-directed and neuroprotective approaches, although its clinical efficacy remains to be fully established [88]

In addition to the presented results, significant future applications of AuNCs may be in imaging of carbonylated proteins in fixed or live cells, allowing for quantification, as well as localization and transport studies of carbonylated proteins

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To inhibit autophagy, vitiligo melanocytes were grown in M254 containing HMGS and treated with the autophagy inhibitor 3-methyl adenine (5 mM) (Sigma Aldrich) for 24-48-72-96 h whereas vitiligo fibroblasts were cultured in DMEM with 10% FBS and incubated with the inhibitor 3-methyl adenine (5 mM) (Sigma Aldrich) for 24 and 48 h