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Per FY2026 ICD-10-CM Official Guidelines, the 6th character for complications is required when documented

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Similarly, patients with mild to moderate renal impairment may require closer monitoring during dose titration, though specific dose adjustments are not typically necessary based solely on renal function

PLoS Med 12:e1001779

Preclinical studies in rodents have demonstrated reductions in fat mass, improved insulin sensitivity, and increased metabolic rate without significant changes to food intake (Neelakantan et al., 2019)

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