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Chronic Fatigue B-12 helps correct deficiencies that are often behind persistent tiredness

Hormones 23:675681

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This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD (Gu et al., 2013), which may impair the conversion of pyruvate to acetyl-CoA, leading to mitochondrial dysfunction and accumulation of lactate and alanine

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E.OzkanF.et al (2016)