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Whether managing a hectic schedule or simply aiming to feel your best, the benefits of B12 shots extend far beyond energy and skin health

[5] It does not appear to significantly alter glucose tolerance, insulin sensitivity, or IGF-1 levels, though more research is needed to further support these hypotheses

Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist that was originally developed for type 2 diabetes management and subsequently approved by the FDA for chronic weight management under the brand name Wegovy

A fasting insulin-raising allele at IGF1 locus is associated with circulating levels of IGF-1 and insulin sensitivity

This can hinder drug effectiveness, as some drugs degrade in the acidic stomach environment or due to gut enzymes (82)

But this is also where things get more complicated