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A retrospective study on patients with mild cognitive impairment ( n = 25) on 9-18 months of melatonin (3-9 mg) showed better performance in the Mini Mental State Examination (MMSE), the cognitive subscale of the Alzheimers Disease Assessment Scale, and multiple neuropsychological tests [246]

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The most commonly reported side effects in clinical trials include injection site reactions (redness, swelling, itching), fluid retention, joint pain, and in some cases transient glucose elevation

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