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Chronic Diseases Influenced by ROS-Modalities of Action The ROS Sources Free radicals are generally produced as a result of the influence of external factors, such as pollution, cigarette smoke, or internally, as a result of intracellular metabolism if the antioxidant mechanisms are overwhelmed (Figure 1)

Acknowledgements This work is supported by the National Natural Science Foundation of China (22172008, L.F

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This trial was the first to evaluate the use of oral N-acetylcysteine in monotherapy, associated with broad-spectrum sunscreen, for the treatment of melasma

ChIP-enriched chromatin was used for real-time PCR

The activation of the EGFR signaling pathway represents a robust mitogenic signal in LR