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Epigenetic-metabolic interface analyses in target validation projects

In the skin of mice, imiquimod and the resulting inflammation enables the skin to have a more rapid Aim2-mediated response to a secondary inflammatory insult 28 , suggesting that epigenetic reprogramming of inflammasome components may be a common mechanism for priming inflammation sensors to prepare for secondary exposure at barrier tissue sites

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Male Wistar rats not subjected to ruthenium red toxicity (60 g/kg, IP) but treated with 10 mg/kg (IP) all showed significant increases of up to 166% in complex I and IV activity levels in the liver and brain mitochondria in a time-dependent manner