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By the fourth day of training, considered to be a crucial day on which the most improvement in training and neural plasticity occurs (Meighan et al., 2006), the scopolamine group (mean latency to find the pedestal = 102.4 s) and the scopolamine + Hinge Dihexa group (mean latency = 105.2 s) showed no signs of improvement compared to the vehicle control group (mean latency = 43.0 s), the Hinge group (mean latency = 78.3 s) and the scopolamine -Dihexa group (mean latency = 63.0 s)

Notably, phBECs differentiated from IPF-derived basal cells mimicked typical properties of IPF airway epithelium including an increase in secretory cells and a loss of ciliated cells 71,72 , indicating epigenetic reprogramming of airway basal cells that is maintained in culture 68

Activated ERK1 phosphorylates the threonine 38 residue of ETS1 to induce transcriptional activation [124]