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Cheng S, Wan X, Yang L, Qin Y, Chen S, Liu Y, Sun Y, Qiu Y, Huang L, Qin Q, et al

Do not shake your medication or aggressively mix it

however, none of them has yet been translated to clinical use, possibly due to their low binding affinity and impermeability to the blood-brain barrier

In accordance with our immunoblot experiments, no significant reduction of the RNF4 protein level was detected upon treatment of cells with the PROTACs