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CM from endothelial cells exposed to the viral S1 protein triggered rapid activation of the IL-6/STAT3 axis in HMC3 cells, linking vascular infection to secondary microglia-driven neuroinflammatory responses (311)

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Heme is an important inhibitor of BACH2, which represses transcription of Blimp-1 138

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24 h) incorporation in the extracellular space when compared with control (baseline) A7r5 cells (Fig

The ensuing phagocytosis of RBCs may lead to iron overload within macrophages, which has been shown to cause progressive macrophage dysfunction, inflammatory M1 polarization, increased ferroptosis and exacerbated atherosclerosis 66,67,68,69,70,71