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Herbal medicines could disrupt hypoxia-angiogenesis crosstalk to achieve synergy effects

For example, microbial metabolites, including SCFAs and bile acids, can regulate Treg differentiation and TGF- secretion

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10.1023/b:jmsm.0000032818.09569.d9 42 ElangoJ.SelvaganapathyP

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INTRODUCTION The introduction of cocaine as the first local anesthetic (LA) in the late nineteenth century was soon accompanied by reports of its systemic toxicity